Young children rarely develop hemochromatosis. Avoid uncooked fish and shellfish. The TS test shows how much iron the transferrin is carrying. The Clinical Practice Guidelines (the guidelines) have been developed by the guidelines and Protocols Advisory Committee on behalf of the Medical Services Commission. Talk about how you feel with your health care team. Drinking alcohol increases the risk of liver disease. The two faulty genes cause your body to absorb more iron than usual from the foods you eat. Parents, grandparents, brothers and sisters, and children (blood relatives) of a person who has hemochromatosis may be at risk for the disease. U.S. Department of Health & Human Services, COVID-19 is an emerging, rapidly evolving situation, Get the latest public health information from CDC, Get the latest research information from NIH, Get the latest information and resources from NHLBI, NIH staff guidance on coronavirus (NIH Only), Obesity, Nutrition, and Physical Activity, NHLBI Diversity, Equity and Inclusion Statement, Customer Service/Center for Health Information, Atransferrinemia and aceruloplasminemia—both are rare, inherited diseases, Chronic liver diseases, such as chronic hepatitis C infection, alcoholic liver disease, or nonalcoholic steatohepatitis, Oral iron pills or iron injections, with or without very high vitamin C intake (vitamin C helps your body absorb iron), Liver disease, including an enlarged liver, liver failure, liver cancer, or cirrhosis (scarring of the liver), Diabetes, especially in people who have a family history of diabetes, Joint damage and pain, including arthritis, Reproductive organ failure, such as erectile dysfunction (impotence), shrinkage of the testicles, and loss of sex drive in men, and absence of the menstrual cycle and early menopause in women, Changes in skin color that make the skin look gray or bronze, Hematologists (blood disease specialists), Endocrinologists (gland system specialists), Gastroenterologists (digestive tract specialists), Rheumatologists (specialists in diseases of the joints and tissues). Your doctor may test your serum ferritin level if your TS level is high. If you were certified before 2004, participation in the ASCP Credential Maintenance Program is voluntary but highly encouraged. A phlebotomy is a simple and safe procedure. People who have hemochromatosis (or a family history of it) and are planning to have children may want to consider genetic testing and counseling. This leads to too much iron in the body. Carriers usually don't develop the disease. After your iron levels return to normal, you may continue phlebotomy treatments. Reducing the amount of iron in your body to normal levels, Preventing or delaying organ damage from iron overload, Maintaining a normal amount of iron in your body for the rest of your life. Hemochromatosis, a disease caused by a mutation in the hemochromatosis (HFE) gene, is associated with an excessive buildup of iron in the body [3,40,95]. If you have hemochromatosis, liver function tests may show the severity of the disease. In men, complications such as diabetes or cirrhosis (scarring of the liver) often are the first signs of the disease. Signs and symptoms of hemochromatosis usually don't occur until middle age. In the first stage of treatment, about 1 pint of blood is removed once or twice a week. Talk with your doctor about how much vitamin C is safe for you. Treatments include removing blood (and iron) from your body, medicines, and changes in your diet. Learn vocabulary, terms, and more with flashcards, games, and other study tools. The guidelines are intended to give an understanding of a clinical problem, and outline one or more preferred approaches to the investigation and management of the problem. It stores it in body tissues, especially the liver, heart, and pancreas. Primary hemochromatosis is an inherited disease. Signs and symptoms also vary based on the severity of the disease. 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